American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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Prepare for the American Board of Surgery Qualifying Exam with flashcards and multiple choice questions. Each question includes explanations to enhance understanding. Boost your confidence and readiness for the exam!

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Cisplatin is most notable for which of the following toxicities?

Acoustic nerve damage
Hemorrhagic cystitis
Myelosuppression
Increased hepatotoxicity

The correct answer is: Acoustic nerve damage

Cisplatin is primarily associated with ototoxicity, which can lead to hearing loss and dysfunction of the acoustic nerve. This is a notable and well-documented toxicity related to its use, particularly in patients undergoing treatment for various malignancies. The damage to the inner ear structures results from the accumulation of the drug in the cochlea, causing cellular apoptosis and leading to auditory impairment. While other toxicities are associated with different chemotherapeutic agents, cisplatin's distinctive ototoxic effect sets it apart, making it essential for clinicians and patients to be aware of this potential side effect. Safe administration practices and monitoring of auditory function can help manage this risk effectively.