American Board of Surgery Qualifying Exam (ABS QE) Practice Test

In MEN 2B syndrome, which physical condition is commonly associated?

1. Marfanoid habitus

2. Irritable bowel syndrome

3. Hemochromatosis

4. Chronic pancreatitis

The correct answer is: Marfanoid habitus

In MEN 2B syndrome, the presence of a marfanoid habitus is commonly associated. MEN 2B, also known as Multiple Endocrine Neoplasia type 2B, is a genetic condition caused by mutations in the RET proto-oncogene. One of the hallmark features of this syndrome is the marfanoid phenotype, characterized by tall stature, long limbs, and hypermobility of the joints, resembling features typical in Marfan syndrome. However, the marfanoid characteristics in MEN 2B can be attributed to the underlying genetic mutation and connective tissue abnormalities resulting from it. The other options do not have a direct association with MEN 2B. Irritable bowel syndrome is a functional gastrointestinal disorder that is not specifically linked to MEN 2B pathology. Hemochromatosis is a condition related to iron overload rather than a consequence of the genetic mutations seen in MEN syndromes, and chronic pancreatitis is more commonly associated with other risk factors rather than MEN 2B. Understanding the specific clinical features and associations of MEN 2B helps in diagnosing and managing these patients effectively.