American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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What combination of serological markers indicates that a person is infected and immune, not requiring vaccination?

  1. HBsAg -, HBsAb -, HBcAb -

  2. HBsAg -, HBsAb +, HBcAb +

  3. HBsAg +, HBsAb +, HBcAb -

  4. HBsAg -, HBsAb +, HBcAb -

The correct answer is: HBsAg -, HBsAb +, HBcAb +

The combination of serological markers that indicates a person is infected and immune, therefore not requiring vaccination, is best represented by the markers showing HBsAg negative, HBsAb positive, and HBcAb positive. In this serological profile, HBsAg negative signifies that an individual is not currently infected with the hepatitis B virus. The presence of HBsAb indicates that the person has developed antibodies against hepatitis B, which is a sign of immunity—either from past infection or vaccination. The HBcAb positive marker shows that there has been a past exposure to the virus, confirming that the individual has recovered from the infection and has formed a protective immune response. This combination effectively demonstrates a resolved hepatitis B infection with subsequent immunity, indicating that further vaccination would not be necessary.

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