American Board of Surgery Qualifying Exam (ABS QE) Practice Test

Which of the following is a notable side effect of Cyclosporin?

1. Fatigue

2. Nephrotoxicity

3. Constipation

4. Hypertension

The correct answer is: Nephrotoxicity

Nephrotoxicity is a well-recognized side effect of Cyclosporin, an immunosuppressant medication commonly used to prevent organ transplant rejection and manage autoimmune conditions. The drug primarily exerts its effects by inhibiting the activation of T-lymphocytes, but it can also have significant impacts on renal function. The mechanism of nephrotoxicity typically involves the constriction of afferent arterioles and other direct effects on renal vasculature, leading to decreased renal blood flow and often resulting in rising serum creatinine levels. This side effect is pivotal when monitoring patients on Cyclosporin, as impaired kidney function can lead to complications that may affect dosage adjustments and overall management. Recognizing nephrotoxicity is critical for maintaining patient safety and ensuring effective therapy. While fatigue, constipation, and hypertension can also occur as side effects of various medications, nephrotoxicity is particularly associated with Cyclosporin and requires vigilance from healthcare providers to mitigate risks and manage the condition effectively.