American Board of Surgery Qualifying Exam (ABS QE) Practice Test

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Which of the following syndromes is associated with a parathyroid tumor, pituitary tumor, and pancreas tumor?

  1. MEN 1

  2. MEN 2A

  3. MEN 2B

  4. None of the above

The correct answer is: MEN 1

The correct answer is associated with Multiple Endocrine Neoplasia Type 1 (MEN 1), also known as Wermer's syndrome. MEN 1 is characterized by a triad of tumors affecting the parathyroid glands, the pituitary gland, and the pancreas. This hereditary condition results from mutations in the MEN1 gene, leading to the development of these endocrine tumors. In MEN 1, patients often present with hyperparathyroidism due to parathyroid tumors, which can lead to elevated calcium levels and related complications. Additionally, pituitary tumors in MEN 1 can result in various hormonal imbalances depending on the type (e.g., prolactinomas leading to galactorrhea, or growth hormone-secreting tumors leading to acromegaly). Pancreatic endocrine tumors can manifest as gastrinomas, insulinomas, or glucagonomas, each causing specific clinical syndromes. This distinct triad of tumors differentiates MEN 1 from MEN 2A and MEN 2B. MEN 2A typically involves medullary thyroid carcinoma, pheochromocytomas, and primary hyperparathyroidism, while MEN 2B includes medullary thyroid carcinoma, pheochromocytomas,

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