American Board of Surgery Qualifying Exam (ABS QE) Practice Test

Which statement describes the growth characteristics of Luminal B breast cancer?

1. Slow growth, good prognosis

2. Fast growth, poor prognosis

3. Static growth, indeterminate prognosis

4. Moderate growth, excellent prognosis

The correct answer is: Fast growth, poor prognosis

Luminal B breast cancer is characterized by its fast growth and generally poorer prognosis compared to Luminal A type breast cancers. This subtype is often hormone receptor-positive and may have higher levels of Ki-67, a marker that indicates a higher proliferation rate of cancer cells. The rapid growth can lead to a more aggressive disease course, making early detection and treatment critical for patient outcomes. In addition to the proliferative characteristics, Luminal B tumors often present at a later stage and are more likely to recur after treatment compared to Luminal A tumors which typically exhibit slower growth and more favorable outcomes. These clinical features underscore the importance of tailored treatment strategies for Luminal B breast cancer to address its aggressive nature. Understanding these growth characteristics helps in managing the treatment plans more effectively and provides insight into counseling patients regarding their prognosis and therapeutic approaches.